The Students at the Center framework defines a core set of research-backed principles that are known to drive powerful teaching and learning and designed to ensure that all students develop the sorts of high-level knowledge, skills, and dispositions they need to succeed in college, careers, and civic life. These four key principles of student-centered learning—drawn from the mind/brain sciences, learning theory, and research on youth development—are overlapping and complementary. In combination, and when guided by a coherent and rigorous set of educational goals, they provide a strong foundation for the pursuit of deeper learning.